Liver transcriptomic profile of 3 months old wild type and hepatocyte-specific ATF6 overexpression mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 7 × Tg vs 5 × WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Activated ATF6α is a hepatic tumour driver restricting immunosurveillanceNature · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE244212_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1021674 and SRA study SRP463562. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7808713 WT_15729 WT
- GSM7808714 WT_13011 WT
- GSM7808715 WT_13012 WT
- GSM7808716 WT_13013 WT
- GSM7808717 WT_13014 WT
- GSM7808718 Tg_15014 Tg
- GSM7808719 Tg_15116 Tg
- GSM7808720 Tg_15119 Tg
- GSM7808721 Tg_13010 Tg
- GSM7808722 Tg_15807 Tg
- GSM7808723 Tg_15845 Tg
- GSM7808724 Tg_15843 Tg
- GSE244213 Liver transcriptomic profile of 6 months old wild type and hepatocyte-specific ATF6 overexpression mice 13 samples shares atf6, hepatocyte-specific, overexpression, months, liver, wild, type
- GSE285265 Liver transcriptomic profile of wild type and hepatocyte-specific ATF6 knockout mice feeding CD-HFD 11 samples shares atf6, hepatocyte-specific, liver, wild, type
- GSE293041 Single-cell transcriptome analysis of wildtype, TREM2 knockout, GPR34 knock-out or TREM2/GPR34 double knock-out primary microglia from wildtype and APP knock-in mice (8 months) 10 samples shares months, wild, type
- GSE339349 Physiological YAP activation alleviate ER stress to mitigate alcohol-induced liver damage by promoting ATF6 transcriptional activation 18 samples shares atf6, liver
- GSE223049 Bulk RNA-seq in young (2 months) and aged (22-24 months) mice across 23 cell-types 170 samples shares months, type
- GSE309118 Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice 42 samples shares hepatocyte-specific, liver
- GSE283998 MBNL overexpression rescues cardiac phenotypes in a myotonic dystrophy type 1 heart mouse model 36 samples shares overexpression, type
- GSE293093 RNA Seq of hearts upon hepatocyte-specific overexpression of REV-ERBα in cancer cachexia 29 samples shares hepatocyte-specific, overexpression
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.