← BioTransfer GEO Dataset Finder
GEO series

Genetic deletion of RUNX1 or RUNX2 in adipocytes enhanced beige fat formation [ATAC-seq]

GSE292124 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/02/12 Platform GPL34290
Summary
To uncover novel transcriptional regulatory mechanisms of brown adipogenesis, we performed Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) to map genome-wide chromatin accessibility during the early stages of immortalized primary brown preadipocytes differentiation.Intriguingly, we identified a significant enrichment of the RUNX transcription factor binding motif within brown preadipocyte-specific peaks, suggesting a previously unrecognized role of the RUNX family as a potential barrier to brown adipogenesis
Published in
Inhibition of adipocyte RUNX1/2 enhances adipose tissue thermogenesis through distinct mechanisms
Wang C, He N, Wang S et al. · Nature communications 2026 · PMID 41927567 · doi:10.1038/s41467-026-71266-6
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE292124_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1237235 and SRA study SRP570883. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.