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RNA-seq of macrophages treated with or without MLN4924

GSE292171 Homo sapiens Expression profiling by high throughput sequencing 5 samples Submitted 2025/11/18 Platform GPL15433
Summary
MLN4924, a neddylation inhibitor with potential in cancer treatment, has anti - inflammatory effects. As atherosclerosis is an inflammatory disease related to autophagy and cell senescence, this study explored MLN4924's role in it. Focusing on foam cell formation, a key step in atherosclerosis, results showed MLN4924 downregulated scavenger receptors like CD36, and upregulated cholesterol efflux gene ABCA1. It also inhibited macrophage senescence and SASP - related factors, possibly via enhanced autophagy. Analyses revealed its impact on macrophage transcriptome and metabolism, with genes enriched in the PI3K - AKT pathway. MLN4924 inhibited AKT phosphorylation, regulated gene expression such as ABCA1, and modulated metabolite production. These suggest its potential as an anti - atherosclerotic agent for further research.
Published in
MLN4924 inhibits macrophage foam cell formation by enhancing autophagy and regulating metabolic phenotype
Xing L, Bu Y, Shi J et al. · Lipids in health and disease 2025 · PMID 41039585 · doi:10.1186/s12944-025-02683-7
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Also filed as BioProject PRJNA1237321 and SRA study SRP570924. Searching any of these in the dataset finder brings you back here.

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