RNA-Seq Reveals Enhanced Inflammation and Fibrosis in Alcohol-Induced Liver Injury of Apoe Knockout Mice
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 5 × Ctrl_ApoE vs 5 × EtOH_WT vs 4 × Ctrl_WT vs 4 × EtOH_ApoEGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Infiltrating macrophages replace Kupffer cells and play diverse roles in severe alcohol-associated hepatitisCellular & molecular immunology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292193_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1237368 and SRA study SRP571100. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 4 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8852329 Ctrl_ApoE1 Ctrl_ApoE
- GSM8852330 Ctrl_ApoE2 Ctrl_ApoE
- GSM8852331 Ctrl_ApoE3 Ctrl_ApoE
- GSM8852332 Ctrl_ApoE4 Ctrl_ApoE
- GSM8852333 Ctrl_ApoE5 Ctrl_ApoE
- GSM8852334 Ctrl_WT1 Ctrl_WT
- GSM8852335 Ctrl_WT2 Ctrl_WT
- GSM8852336 Ctrl_WT3 Ctrl_WT
- GSM8852337 Ctrl_WT4 Ctrl_WT
- GSM8852338 EtOH_ApoE1 EtOH_ApoE
- GSM8852339 EtOH_ApoE2 EtOH_ApoE
- GSM8852340 EtOH_ApoE4 EtOH_ApoE
- GSM8852341 EtOH_ApoE5 EtOH_ApoE
- GSM8852342 EtOH_WT1 EtOH_WT
- GSM8852343 EtOH_WT2 EtOH_WT
- GSM8852344 EtOH_WT3 EtOH_WT
- GSM8852345 EtOH_WT4 EtOH_WT
- GSM8852346 EtOH_WT5 EtOH_WT
- GSE264278 TIme-cource single-cell RNA-seq analysis of bleomycin and LPS-induced lung injury and fibrosis 18 samples shares fibrosis, rna-seq, injury
- GSE274973 Mouse liver assembloids model periportal architecture and biliary fibrosis [scRNA-seq] 13 samples shares fibrosis, rna-seq, liver
- GSE217662 Decoding Trp53 regulatory program with knockout cell transcriptomic landscape analyses [scRNA-seq] 247 samples shares knockout, rna-seq
- GSE319608 Enhanced antisense oligonucleotide delivery reveals that transcript turnover impacts apparent splicing rescue in myotonic dystrophy 98 samples shares enhanced, liver
- GSE235623 MERTK inhibition for the treatment of tissue fibrosis [RNA-seq] 86 samples shares fibrosis, rna-seq
- GSE280003 Gpnmb and Spp1 mark a conserved macrophage injury response masking fibrosis-specific programming in the lung 81 samples shares fibrosis, injury
- GSE296764 Transcriptional expression of SCN, liver and heart at CT0 and CT12 after central VIP knockout of Bmal1 76 samples shares knockout, liver
- GSE295426 Targeting branched-chain amino acids alleviates pulmonary fibrosis [RNA-seq] 54 samples shares fibrosis, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.