MERTK inhibition for the treatment of tissue fibrosis [RNA-seq]
RNA-seq (gene expression) · mouse · 86 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 86 samples: 21 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Inhibition of MERTK reduces organ fibrosis in mouse models of fibrotic diseaseScience translational medicine · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE235623_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA986572 and SRA study SRP445412. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 85 samples.
How we read this: 21 replicated groups read from 86 sample titles; they account for 85 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7506324 UUO Sham WT 1 UUO Sham WT
- GSM7506325 UUO Sham WT 2 UUO Sham WT
- GSM7506326 UUO Sham WT 3 UUO Sham WT
- GSM7506327 UUO Sham WT 4 UUO Sham WT
- GSM7506328 UUO Sham KO 1 UUO Sham KO
- GSM7506329 UUO Sham KO 2 UUO Sham KO
- GSM7506330 UUO Sham KO 3 UUO Sham KO
- GSM7506331 UUO Sham KO 4 UUO Sham KO
- GSM7506332 UUO WT 1 UUO WT
- GSM7506333 UUO WT 2 UUO WT
- GSM7506334 UUO WT 3 UUO WT
- GSM7506335 UUO WT 4 UUO WT
- GSM7506336 UUO KO 1 UUO KO
- GSM7506337 UUO KO 2 UUO KO
- GSM7506338 UUO KO 3 UUO KO
- GSM7506339 UUO KO 4 UUO KO
- GSM7506340 BDL Sham WT 1 BDL Sham WT
- GSM7506341 BDL Sham WT 2 BDL Sham WT
- GSM7506342 BDL Sham WT 3 BDL Sham WT
- GSM7506343 BDL Sham WT 4 BDL Sham WT
- GSM7506344 BDL Sham KO 1 BDL Sham KO
- GSM7506345 BDL Sham KO 2 BDL Sham KO
- GSM7506346 BDL Sham KO 3 BDL Sham KO
- GSM7506347 BDL Sham KO 4 BDL Sham KO
- GSM7506348 BDL WT 1 BDL WT
- GSM7506349 BDL WT 2 BDL WT
- GSM7506350 BDL WT 3 BDL WT
- GSM7506351 BDL WT 4 BDL WT
- GSM7506352 BDL KO 1 BDL KO
- GSM7506353 BDL KO 2 BDL KO
- GSM7506354 BDL KO 3 BDL KO
- GSM7506355 BDL KO 4 BDL KO
- GSM7506356 BILE DUCT LIGATION (BDL)+DMSO 1 BILE DUCT LIGATION (BDL…
- GSM7506357 BILE DUCT LIGATION (BDL)+DMSO 2 BILE DUCT LIGATION (BDL…
- GSM7506358 BILE DUCT LIGATION (BDL)+DMSO 3 BILE DUCT LIGATION (BDL…
- GSM7506359 BILE DUCT LIGATION (BDL)+ MERTK INHIBITOR(UNC569) 1 BILE DUCT LIGATION (BDL…
- GSM7506360 BILE DUCT LIGATION (BDL)+ MERTK INHIBITOR(UNC569) 2 BILE DUCT LIGATION (BDL…
- GSM7506361 BILE DUCT LIGATION (BDL)+ MERTK INHIBITOR(UNC569) 3 BILE DUCT LIGATION (BDL…
- GSM7506362 BILE DUCT LIGATION (BDL)+ MERTK INHIBITOR(UNC569) 4 BILE DUCT LIGATION (BDL…
- GSM7506363 BILE DUCT LIGATION (BDL)+ MERTK INHIBITOR(UNC569) 5 BILE DUCT LIGATION (BDL…
+ 46 more — browse all 86 samples with per-sample file links →
- GSE332646 Bulk RNA-seq of juvenile mouse liver following NDMA or saline treatment in WT and Mgmt-/- genotypes across multiple timepoints 214 samples shares treatment, rna-seq
- GSE286519 Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGFβ axis [RNA-seq] 31 samples shares inhibition, rna-seq
- GSE264278 TIme-cource single-cell RNA-seq analysis of bleomycin and LPS-induced lung injury and fibrosis 18 samples shares fibrosis, rna-seq
- GSE292193 RNA-Seq Reveals Enhanced Inflammation and Fibrosis in Alcohol-Induced Liver Injury of Apoe Knockout Mice 18 samples shares fibrosis, rna-seq
- GSE268791 TGF-b/Smad3 inhibition synergizes with PPARg agonism to reduce fibrosis and enhance functional beige adipogenesis 18 samples shares inhibition, fibrosis
- GSE281480 Bulk RNA-seq of immunopanned astrocytes with the treatment of Shh and Fgf 17 samples shares treatment, rna-seq
- GSE271662 RNA-seq of Mouse Spinal Cord after Lateral Compression Spinal Cord Injury followed by Delayed Atorvastatin or Vehicle Treatment [Bulk RNA-seq of mice spinal cords] 16 samples shares treatment, rna-seq
- GSE328496 Gene expression + ATAC profiling of trisomic hippocampal neurons upon SAHA treatment [RNA-seq] 16 samples shares treatment, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.