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Hypoxia differentially affects coronary vessel formation during heart development

GSE292395 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/06/10 Platform GPL30172
Summary
The coronary vessel system is a dense and diverse network of arteries, veins and capillaries formed by endothelial cells from a variety of sources. While hypoxia is a known stimulus for angiogenic sprouting, the exact mechanisms by which hypoxia - and resultant increased VEGFA - influences vessel growth in the heart are not clearly delineated. We used a genetic mouse model to mimic hypoxia through ectopic stabilisation of myocardial HIFα. This enabled us to study the consequences of hypoxia without vascular depletion. Changes in coronary ECs in these hearts relative to littermate controls were assessed by single cell RNA-sequencing. This identified increased angiogenic gene expression and a shift towards a non-proliferative, migratory tip cell phenotype.
Published in
Hypoxia differentially affects coronary vessel formation during heart development
Payne S, Bruche S, Szumska D et al. · Cardiovascular research 2026 · PMID 42252105 · doi:10.1093/cvr/cvag124
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Also filed as BioProject PRJNA1238307 and SRA study SRP571600. Searching any of these in the dataset finder brings you back here.

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