← BioTransfer GEO Dataset Finder
GEO series

Radon Exposure Delays the Development of Skin Lesions in a Mouse Model of Psoriasis

GSE292505 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/11/04 Platform GPL19057
Summary
We used transgenic mice that spontaneously develop chronic psoriatic skin lesions inflicted (CD11c-IL-17Aind/ind mice) to investigate effects induced by multiple radon exposures. Comprehensive transcriptome profiling of non-lesional skin showed downregulation of genes associated with psoriasis initiation, while anti-inflammatory genes were upregulated. Pathway enrichment analysis revealed immunosuppressive effects related to T cell regulation, similar to UV radiation-induced response.
Published in
Radon exposure delays the development of skin lesions in a mouse model of psoriasis
Lerchl S, Wiedemann J, Maier A et al. · Frontiers in immunology 2025 · PMID 41341581 · doi:10.3389/fimmu.2025.1638483
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE292505_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1238879 and SRA study SRP571934. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.