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Effect of hepatic FPN ablation on the liver transcriptome in mice

GSE292556 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/14 Platform GPL24247
Summary
Iron overload has emerged as a key risk factor for MASLD and metabolic disorders. We explored the effects of hepatocyte-specific knockout of ferroportin (FPN), the only known iron exporter, on the pathogenesis of MASLD and the associated metabolic dysfunction. To investigate the molecular basis, we carried out RNA-sequencing analysis using liver samples from littermate control and hepatocyte-specific Fpn KO mice.
Published in
Iron overload in steatotic hepatocytes drives systemic metabolic dysfunction via alterations in hepatokine production
Jo HJ, Kim A, Rho H et al. · The Journal of clinical investigation 2026 · PMID 42048168 · doi:10.1172/JCI196374
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Also filed as BioProject PRJNA1240208 and SRA study SRP572161. Searching any of these in the dataset finder brings you back here.

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