A pilot trial of perioperative IDH Inhibition in treatment-naïve IDH-mutant glioma
RNA-seq (gene expression) · human · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Lower-grade gliomaThis series is part of our curated briefing on it.
- Samples
- 11 samples: 11 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trialNature medicine · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292732_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1241178 and SRA study SRP572661. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 11 sample titles: 11 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8864443 Patient A astrocytoma tumor resection
- GSM8864444 Patient B astrocytoma tumor resection
- GSM8864445 Patient C astrocytoma tumor resection
- GSM8864446 Patient D astrocytoma tumor resection
- GSM8864447 Patient E astrocytoma tumor resection
- GSM8864448 Patient F astrocytoma tumor resection
- GSM8864449 Patient G astrocytoma tumor resection
- GSM8864450 Patient H astrocytoma tumor resection
- GSM8864451 Patient A oligodendroglioma tumor resection
- GSM8864452 Patient B oligodendroglioma tumor resection
- GSM8864453 Patient C oligodendroglioma tumor resection
- GSE260997 Mutant IDH inhibitors induce lineage differentiation in IDH-mutant Oligodendroglioma III 2458 samples same disease briefing · shares idh, idh-mutant, glioma
- GSE326221 Acquired genetic and cell state changes in IDH-mutant glioma progression [snRNA-seq] 75 samples same disease briefing · shares idh, idh-mutant, glioma
- GSE226321 Multimodal integration of transcriptomics, proteomics and radiomics improves prediction of recurrence in patients with IDH-mutant Glioma 59 samples same disease briefing · shares idh, idh-mutant, glioma
- GSE308634 Transcriptional changes mediated by the HDACi panobinostat in IDH-wildtype and IDH-mutant gliomas 54 samples same disease briefing · shares idh, idh-mutant, glioma
- GSE308636 Transcriptional changes mediated by the HDACi belinostat in IDH-mutant glioma cultures with YAP and TAZ overexpression 36 samples same disease briefing · shares idh, idh-mutant, glioma
- GSE252245 Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib 24 samples same disease briefing · shares idh, idh-mutant, glioma
- GSE260928 Mutant IDH inhibitors induce lineage differentiation in IDH-mutant Oligodendroglioma I 10 samples same disease briefing · shares idh, idh-mutant, glioma
- GSE270109 Single-Cell Sequencing of IDH-Mutant Glioma 4 samples same disease briefing · shares idh, idh-mutant, glioma
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.