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MCF7 and MDA-MB-231 RNA-seq

GSE292767 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/11/06 Platform GPL16791
Summary
LCOR is a corepressor of activated nuclear receptors that inhibits the transcriptional activity of these proteins. Recently, LCOR was described to act also as a transcription activator by DNA direct binding through its HTH domain of genes involved in antigen presentation. This double transcriptional role of LCOR is determined by the expression of nuclear receptor. We overexpressed LCOR and performed RNA-seq in breast cancer cell lines of nuclear receptor positive subtype (MCF7) and nuclear receptor absent (MDA-MB-231). This analysis allows to compare transcriptional regulation of LCOR depending on the presence of nuclear receptors.
Published in
Estrogen receptor signaling drives immune evasion and immunotherapy resistance in HR+ breast cancer
Palomeque JÁ, Serra-Mir G, Blasco-Benito S et al. · The Journal of clinical investigation 2026 · PMID 41289011 · doi:10.1172/JCI193153
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Also filed as BioProject PRJNA1241224 and SRA study SRP573087. Searching any of these in the dataset finder brings you back here.

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