GEO series
Dlx1&2 Directly Promote Expression of Cxcl14 to Control Synapse Development and Interneuron Survival [ChIP-seq]
GSE292837
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
10 samples
2026/05/01
GPL24247
Summary
Dlx genes have fundamental roles in the generation, differentiation and functions of virtually all forebrain GABAergic neurons. Here we focused on defining the key genes that are dysregulated in Dlx1/2 conditional mutants in mouse immature cortical GABAergic interneurons (CINs), and by identifying DLX-bound putative regulatory elements (pREs) of these Dlx-regulated genes. Within the Dlx-expressing lineage, some DLX-bound pREs were specific to CINs, others appeared to be constitutively bound; the latter class having activity in mature CINs. One such pRE and its associated gene, Cxcl14, is strongly activated by Dlx1/2 and is essential for synaptogenesis onto CINs and for CIN survival.
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