GEO series
Features of Group 3-like medulloblastoma mouse model [RNA-Seq]
GSE292964
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2026/03/25
GPL24247
Summary
Group 3 medulloblastoma is the most aggressive among the four medulloblastoma subgroups, with poor prognosis and early metastasis making treatment particularly challenging. The lack of an immune-competent mouse model has hindered effective in vivo testing of potential drugs and mechanisms. Given the prevalent MYC overexpression in Group 3 medulloblastoma, we developed a Group 3-like medulloblastoma mouse model in C57BL/6J mice by overexpressing MYC in the cerebellum of newborn pups. This model provides a valuable tool for studying Group 3 medulloblastoma more effectively.
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