GEO series
Transcriptomic comparison of hepatocytes derived from a panel of human induced pluripotent stem cells with different ethnicities
GSE293032
Homo sapiens
Expression profiling by high throughput sequencing
54 samples
2025/04/21
GPL30173
Summary
In the current study, we attempted to establish an in vitro model for assessing population variability in hepatotoxicity testing using a panel of hepatocytes derived from nine human induced pluripotent stem cell (iPSC) lines belonging to three different ethnic groups, Black or African American (BAA), Latino or Hispanic (LOH), and Non-Hispanic White (NHW). The panel of iPSC-derived hepatocytes were exposed to diglycolic acid (DGA) and usnic acid (UA), and transcriptomic changes were characterized and compared.
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Paper (PMID 40496982) ↗
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