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Targeting microglial PPARα ameliorates the outcome of ischaemic stroke by enhancing interaction with infiltrating peripheral monocytes/macrophages

GSE293414 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/01 Platform GPL24247
Summary
Microglial PPARα downregulation enhances inflammation and worsens ischemic brain injury by promoting Mo/MΦ infiltration, shifting them to a proinflammatory state, and disrupting the BBB. Restoring PPARα expression via AAV transfection reverses these effects, exerting neuroprotection by enhancing microglia–macrophage crosstalk through IL-4 signaling. Targeting microglial PPARα may offer a therapeutic strategy for mitigating acute ischemic stroke.
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Also filed as BioProject PRJNA1244387 and SRA study SRP575971. Searching any of these in the dataset finder brings you back here.

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