GEO series
Germline-somatic liaison dictates cancer subtype via de novo steroid biosynthesis
GSE293478
Homo sapiens
Expression profiling by high throughput sequencing
29 samples
2025/06/03
GPL16791
Summary
This study investigates the cooperation between germline genetic variants and somatic mutations in prostate cancer. Specifically, we dissected the interplay between a germline variant at the 7p14.3 locus (rs1376350, G>A) and early recurrent prostate cancer-specific mutation in the Speckle-Type POZ protein (SPOP) gene across human prostate adenocarcinomas. The transcriptomes of multiple edited models pointed to Gli3 and the Hedgehog signaling pathway in a genotype-specific manner.
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Paper (PMID 40512155) ↗
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