GEO series

Roles of the nuclear receptor corepressor 1 (NCoR1) and the silencing mediator of retinoid and thyroid hormone receptors (SMRT) in the developing brain

GSE293505 Mus musculus (mouse) RNA-seq (gene expression) 20 samples Submitted 2026/06/14 Platform GPL19057

At a glance

RNA-seq (gene expression) · mouse · 20 samples

What it is: RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism: Mus musculus (mouse)
Samples: 20 samples
Data you can get: A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.

Summary (written by the submitters)

The nuclear receptor corepressor 1 (NCoR1) and the silencing mediator of retinoic acid and thyroid hormone (SMRT) are critical coregulators of nuclear receptors, including the thyroid hormone receptor and they mediate transcriptional repression via histone deacetylation. Although they are highly homologous and have similar receptor interacting domains, they have different roles in different tissues.

Read the full summary ↓

Recently, de novo genetic variants in nuclear corepressors were found in pediatric patients with neurodevelopmental disorders. Thus, we generated novel mouse models to understand the role of NCOR1 and SMRT in the central nervous system. We used the mice with conditional NCoR1 or SMRT (NCoR1lox/lox or SMRTlox/lox) alleles in combination with the mice that express Cre recombinase in a neuronal specific fashion (Snap25-IRES2-cre). First, we performed behavioral tests to assess for any behavioral phenotypes. We found hypoactivity, social deficits, and mild anxiety in neuronal specific deletion of NCoR1 or SMRT KO mice. In addition, NCoR1 KO mice displayed higher learning abilities in a pairwise visual discrimination task. Next, we performed RNA-sequencing analysis with cells from the amygdala taken at postnatal day 21 to investigate gene expression mediated by NCoR1 and SMRT. We found that 449 genes were upregulated by SMRT deletion, whereas only 8 genes were upregulated by NCoR1 deletion. Overall, our data demonstrate that NCoR1 and SMRT have separate functions in the central nervous system.

This dataset

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Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE293505_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1244834 and SRA study SRP575799. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗

Samples in this study

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+ 20 more — browse all 20 samples with per-sample file links →

Datasets on a similar topic

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GSE276009 Comparative Single Cell Transcriptome Analysis of c-Met Receptor Expressing and Non-Expressing Projection Neurons in the Developing Frontal and Visual Cortices 12 samples shares developing, receptor
GSE160057 BAHD1 links H3K27me3 to gene silencing via a conserved BAH reader module and associated corepressor complex in mammalian cells (RNA-Seq) 12 samples shares corepressor, silencing
GSE160056 BAHD1 links H3K27me3 to gene silencing via a conserved BAH reader module and associated corepressor complex in mammalian cells (CUT&RUN) 4 samples shares corepressor, silencing
GSE290464 Noncanonical role of NCOR1 as a facilitator of DNA mismatch repair and its deficiency sensitizes cancers to immune checkpoint blockade therapy 18 samples shares ncor1
GSE185984 Low input RNA Sequencing of effector and naive WT and NCOR1-cKO CD4+ Treg cells 12 samples shares ncor1
GSE296317 Hepatic NcoR1 deletion exacerbates ischemia and reperfusion (IR) induced liver injury regulated by NF-kB p65 [sham-IR] 6 samples shares ncor1

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