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A proinflammatory response and polarized differentiation of stromal elements characterizes the murine myeloma bone marrow niche

GSE293547 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/02 Platform GPL24247
Summary
To address the role of the non-hematopoietic bone marrow (BM) niche in multiple myeloma (MM) pathogenesis, we utilized the 5TGM1 murine model. During the asymptomatic precursor stage of the model, we isolated the rare non-hematopoietic cells and performed single-cell RNA sequencing. Using in-silico methods, we characterized the individual cellular components of the niche, their relative abundance, and differentation state both before and after exposure to MM cells, as well as their intercellular interactions. MM cells impact the BM niche by generating a pro-inflammatory microenvironment with MSC differentiation being changed away from osteocyte formation and towards adiopcytes, which helps to generate cell subsets that favor MM growth and survival.
Published in
A proinflammatory response and polarized differentiation of stromal elements characterizes the murine myeloma bone marrow niche
Ghamlouch H, Gagler DC, Blaney P et al. · Experimental hematology & oncology 2025 · PMID 40011943 · doi:10.1186/s40164-025-00606-x
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Also filed as BioProject PRJNA1245160 and SRA study SRP576152. Searching any of these in the dataset finder brings you back here.

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