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GnRHR-expressing LAD2 RNA-seq

GSE293563 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/10/01 Platform GPL24676
Summary
Gonadotrophin releasing hormone (GnRH) from hypothalamus stimulates gonadotrophin secretion from pituitary, followed by the secretion of sex steroid hormones from ovaries. GnRH is also detected in the extra-hypothalamic areas, like trophoblasts at the implantation sites. We have previously studied the association between trophoblasts and mast cells by producing leukemia inhibitory factor (LIF) and matrix metalloprotease (MMP)-9, and here hypothesized another association between the cells via GnRH derived from trophoblasts. We here report the RNA-seq analysis revealed the expressions of LIF, MMP-9, and a NK cell attractor CXCL16 enhanced in a human mast cell line LAD2 with forced-expression of GnRHR (GnRHR-expressing LAD2), when compared to those of control LAD2.
Published in
Aberrant Expression of Gonadotropin-Releasing Hormone Receptor in Human Mast Cells Enhances the Recruitments of Trophoblasts and NK Cells
Matsuzaki T, Hamaguchi H, Ito KR et al. · American journal of reproductive immunology (New York, N.Y. : 1989) 2025 · PMID 40966309 · doi:10.1111/aji.70168
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Also filed as BioProject PRJNA1245254 and SRA study SRP575987. Searching any of these in the dataset finder brings you back here.

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