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Form follows function: Nuclear morphology as a quantifiable predictor of cellular senescence

GSE293637 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/07 Platform GPL24676
Summary
Enlarged or irregularly shaped nuclei are frequently observed in tissue cells undergoing senescence. However, it remained unclear whether this peculiar morphology is a cause or a consequence of senescence and how informative it is in distinguishing between proliferative and senescent cells. Recent research reveals that nuclear morphology can act as a predictive biomarker of senescence, suggesting an active role for the nucleus in driving senescence phenotypes. By employing deep learning algorithms to analyze nuclear morphology, accurate classification of cells as proliferative or senescent is achievable across various cell types and species both in vitro and in vivo. This quantitative imaging-based approach can be employed to establish links between senescence burden and clinical data, aiding in the understanding of age-related diseases, as well as assisting in disease prognosis and treatment response.
Published in
Form follows function: Nuclear morphology as a quantifiable predictor of cellular senescence
Belhadj J, Surina S, Hengstschläger M et al. · Aging cell 2023 · PMID 37845808 · doi:10.1111/acel.14012
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Also filed as BioProject PRJNA1245406 and SRA study SRP576053. Searching any of these in the dataset finder brings you back here.

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