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Single cell map of the adult female mouse urethra reveals epithelial and stromal macrophages with distinct functional identities

GSE293686 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/10 Platform GPL24247
Summary
We have employed single cell RNA-sequencing to create a cellular atlas of the female mouse urethra. The epithelial lining of the urethra is an understudied mucosal barrier. Emerging evidence points to the role of the urethra in pathogen surveillance, sensation and response. To investigate the heterogeneity of the resident immune niche in the adult female mouse urethra, we performed single cell RNA-sequencing which revealed the presence of distinct epithelial-associated and stromal macrophages in the urethra.
Published in
Single cell map of the adult female mouse urethra reveals epithelial and stromal macrophages with distinct functional identities
Jasmine, Samtiya M, Rodrigues R et al. · Mucosal immunology 2025 · PMID 40907791 · doi:10.1016/j.mucimm.2025.09.001
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Also filed as BioProject PRJNA1245693 and SRA study SRP576410. Searching any of these in the dataset finder brings you back here.

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