Beclin1 Deficiency Unlocks Cardiac Lineage Commitment through Convergent Wnt and BMP Signaling Activation
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Beclin1 deficiency unlocks cardiac lineage commitment through convergent Wnt and BMP signaling activationStem cell research & therapy · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE293719_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1246102 and SRA study SRP576245. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8889087 mESCs, shNT, replicate 1, Day0
- GSM8889088 mESCs, shNT, replicate 2, Day0
- GSM8889089 mESCs, shBeclin1, replicate 1, Day0
- GSM8889090 mESCs, shBeclin1, replicate 2, Day0
- GSM8889091 EB, shNT, replicate 1, Day4
- GSM8889092 EB, shNT, replicate 2, Day4
- GSM8889093 EB, shBeclin1, replicate 1, Day4
- GSM8889094 EB, shBeclin1, replicate 2, Day4
- GSM8889095 CM, shNT, replicate 1, Day10
- GSM8889096 CM, shNT, replicate 2, Day10
- GSM8889097 CM, shBeclin1, replicate 1, Day10
- GSM8889098 CM, shBeclin1, replicate 2, Day10
- GSM8889099 CM without GF, shNT, replicate 1, Day10
- GSM8889100 CM without GF, shNT, replicate 2, Day10
- GSM8889101 CM without GF, shBeclin1, replicate 1, Day10
- GSM8889102 CM without GF, shBeclin1, replicate 2, Day10
- GSE298006 Stage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [RNA-Seq] 110 samples shares commitment, activation
- GSE326648 Sexual dimorphism shapes AAK trajectory in Pax6 deficiency mouse model with early immune activation, impaired innervation, and altered tears 40 samples shares deficiency, activation
- GSE306049 Atf3 Deficiency Promotes Mesodermal Commitment and Enhances Endothelial Differentiation in Embryonic Stem Cells 24 samples shares deficiency, commitment
- GSE39656 Braveheart is a long non-coding RNA necessary for cardiac lineage commitment 20 samples shares commitment, cardiac
- GSE254687 PARK7/DJ-1 deficiency modulates microglial activation in response to LPS-induced inflammation 19 samples shares deficiency, activation
- GSE298002 Stage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [CUT&Run] 38 samples shares commitment, activation
- GSE298001 Stage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [ATAC-Seq] 36 samples shares commitment, activation
- GSE288156 Progressive intestinal tumor cell plasticity, Myc activation and loss of Lgr5+ tumor stem cell lineage commitment upon Wnt depletion 14 samples shares commitment, activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.