FRA1 drives melanoma metastasis through an actionable transcriptional network
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 20 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- MelanomaThis series is part of our curated briefing on it.
- Samples
- 20 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- FRA1 drives melanoma metastasis through an actionable transcriptional networkbioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE293767_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1246181 and SRA study SRP576399. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 20 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8889682 1205Lu, si-NT, #1 1205Lu, si-NT, #
- GSM8889683 1205Lu, si-NT, #2 1205Lu, si-NT, #
- GSM8889684 1205Lu, si-NT, #3 1205Lu, si-NT, #
- GSM8889685 1205Lu, si-FOSL1, #1 1205Lu, si-FOSL1, #
- GSM8889686 1205Lu, si-FOSL1, #2 1205Lu, si-FOSL1, #
- GSM8889687 1205Lu, si-FOSL1, #3 1205Lu, si-FOSL1, #
- GSM8889688 A375, si-NT, #1 A375, si-NT, #
- GSM8889689 A375, si-NT, #2 A375, si-NT, #
- GSM8889690 A375, si-NT, #3 A375, si-NT, #
- GSM8889691 A375, si-FOSL1, #1 A375, si-FOSL1, #
- GSM8889692 A375, si-FOSL1, #2 A375, si-FOSL1, #
- GSM8889693 A375, si-FOSL1, #3 A375, si-FOSL1, #
- GSM8889694 A375, FRA1 (CutRun), #1 A375, FRA1 (CutRun), #
- GSM8889695 A375, FRA1 (CutRun), #2 A375, FRA1 (CutRun), #
- GSM8889696 A375, FRA1 (CutRun), #3 A375, FRA1 (CutRun), #
- GSM8889697 A375, IgG (CutRun)
- GSM8889698 1205Lu, FRA1 (CutRun), #1 1205Lu, FRA1 (CutRun), #
- GSM8889699 1205Lu, FRA1 (CutRun), #2 1205Lu, FRA1 (CutRun), #
- GSM8889700 1205Lu, FRA1 (CutRun), #3 1205Lu, FRA1 (CutRun), #
- GSM8889701 1205Lu, IgG (CutRun)
- GSE140150 A rare subpopulation of melanoma cells with low expression of metastasis suppressor NME1 has a neural crest-like phenotype and is highly metastatic in vivo 6 samples same disease briefing · shares metastasis, melanoma
- GSE12391 Melanoma: comparison between common nevi, radial/vertical growth phase melanoma, metastases and dysplastic nevi 114 samples same disease briefing · shares melanoma
- GSE134459 Genome-wide maps of transcriptomic and epigenomic state in melanoma cell lines 73 samples same disease briefing · shares melanoma
- GSE230489 RNA-sequencing of cutaneous melanoma and non-small cell lung cancer biopsies 38 samples same disease briefing · shares melanoma
- GSE100797 Mutational and neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma 25 samples same disease briefing · shares melanoma
- GSE123728 Clinical and Immunologic Activity of a Single Dose of Neoadjuvant PD-1 Blockade and Predictors of Clinical Outcomes in Resectable Melanoma 24 samples same disease briefing · shares melanoma
- GSE130956 Investigation of ST8SIA1 expression in icaritin-treated and untreated melanoma cell lines 12 samples same disease briefing · shares melanoma
- GSE142751 Genome-wide maps of chromatin state in 142 cancer cell lines [cell line] 855 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.