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Obesity-associated TRIM15 promotes the proliferation of esophageal adenocarcinoma through the YY2/FOXRED1 axis

GSE293844 Homo sapiens (human) RNA-seq (gene expression) 24 samples Submitted 2026/01/28 Platform GPL24676
At a glance

RNA-seq (gene expression) · human · 24 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Topic
Esophageal cancerThis series is part of our curated briefing on it.
Samples
24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Obesity-Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 AxisAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Summary (written by the submitters)
Obesity has been identified as an independent risk factor for gastroesophageal reflux disease (GERD) and esophageal adenocarcinoma (EAC). Oxidative stress and inflammation driven by chronic GERD are the main causes of the tumorigenesis of EAC, but the underlying mechanism remains elusive. Here, we identified the inflammation-upregulated E3 ligase, tripartite motif 15 (TRIM15) as a key driver of obesity-associated EAC.
Read the full summary ↓
We demonstrated that TRIM15 promotes the degradation of YY2 through the ubiquitin-proteasome system, which in turn dysregulates the lipid metabolism and enhances the proliferation of EAC cells. Furthermore, we showed that YY2 transcriptionally increases FOXRED1 expression. We then found that FOXRED1 is one of the essential effectors for the TRIM15-induced dysregulation of lipid and energy metabolism in EAC cells. Thus, we identified a novel obesity-associated TRIM15/YY2/FOXRED1 axis that contributes to the proliferation of EAC. Given that lipid metabolism regulates ferroptosis by controlling cellular processes associated with phospholipid peroxidation. We show that the TRIM15/YY2/FOXRED1 axis regulates EAC sensitivity to ferroptosis-inducing compounds by modulating the levels of SLC3A2 and GPX4, providing a therapeutic strategy for EAC.
Published in
Obesity-Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis
Wang H, Yang C, Luo D et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · PMID 41237333 · doi:10.1002/advs.202417330
This dataset
Open GSE293844 in finder → Find more human RNA-seq datasets → Esophageal cancer landscape →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE293844_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1246574 and SRA study SRP576517. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41237333) ↗
Study design
8 conditions, mostly in triplicate
HFD ×3 ND ×3 TRIM15-OE ×3 TRIM15-EV ×3 YY2-sh ×3 YY2-NC ×3 FOXRED1-sh ×3 FOXRED1-NC ×3

Supports a between-group comparison across 24 samples.

How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
More Esophageal cancer datasets

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