A macrophage-predominant, immunosuppressive immune microenvironment and subtype-specific therapeutic vulnerabilities in advanced salivary gland cancer [Single nuclei RNAseq]
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 10 × single nuclei RNA seq of tumor biopsy, Patient vs 2 × single nuclei RNA seq of tumor biopsy, Patient 31, technical vs 2 × single nuclei RNA seq of tumor biopsy, Patient 46, technical vs 2 × single nuclei RNA seq of tumor biopsy, Patient 66, technicalGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A macrophage-predominant immunosuppressive microenvironment and therapeutic vulnerabilities in advanced salivary gland cancerNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE294017_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1247798. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8896638 single nuclei RNA seq of tumor biopsy, Patient 6 single nuclei RNA seq o…
- GSM8896639 single nuclei RNA seq of tumor biopsy, Patient 14 single nuclei RNA seq o…
- GSM8896640 single nuclei RNA seq of tumor biopsy, Patient 18 single nuclei RNA seq o…
- GSM8896641 single nuclei RNA seq of tumor biopsy, Patient 31, technical replicate 1 single nuclei RNA seq o…
- GSM8896642 single nuclei RNA seq of tumor biopsy, Patient 31, technical replicate 2 single nuclei RNA seq o…
- GSM8896643 single nuclei RNA seq of tumor biopsy, Patient 32 single nuclei RNA seq o…
- GSM8896644 single nuclei RNA seq of tumor biopsy, Patient 33 single nuclei RNA seq o…
- GSM8896645 single nuclei RNA seq of tumor biopsy, Patient 42 single nuclei RNA seq o…
- GSM8896646 single nuclei RNA seq of tumor biopsy, Patient 46, technical replicate 1 single nuclei RNA seq o…
- GSM8896647 single nuclei RNA seq of tumor biopsy, Patient 46, technical replicate 2 single nuclei RNA seq o…
- GSM8896648 single nuclei RNA seq of tumor biopsy, Patient 66, technical replicate 1 single nuclei RNA seq o…
- GSM8896649 single nuclei RNA seq of tumor biopsy, Patient 66, technical replicate 2 single nuclei RNA seq o…
- GSM8896650 single nuclei RNA seq of tumor biopsy, Patient 74 single nuclei RNA seq o…
- GSM8896651 single nuclei RNA seq of tumor biopsy, Patient 79 single nuclei RNA seq o…
- GSM8896652 single nuclei RNA seq of tumor biopsy, Patient 85 single nuclei RNA seq o…
- GSM8896653 single nuclei RNA seq of tumor biopsy, Patient 103 single nuclei RNA seq o…
- GSE294016 A macrophage-predominant, immunosuppressive immune microenvironment and subtype-specific therapeutic vulnerabilities in advanced salivary gland cancer [bulk RNA-seq] 95 samples shares macrophage-predominant, immunosuppressive, microenvironment, subtype-specific, vulnerabilities, therapeutic, advanced, salivary
- GSE309595 Longitudinal Analysis of Multiple Myeloma: Therapeutic Response and Immune Microenvironment Dynamics in the Context of Tumor Heterogeneity [scRNA-seq] 270 samples shares microenvironment, therapeutic
- GSE263733 Single-cell transcriptome analysis reveals subtype-specific clonal evolution and microenvironmental changes in liver metastasis of pancreatic adenocarcinoma and their clinical implications 218 samples shares microenvironment, subtype-specific
- GSE269629 Metabolic programs drive function of therapeutic natural killer (NK) cells in low oxygen tumor microenvironments 63 samples shares microenvironment, therapeutic
- GSE290805 Meningioma microenvironment harbors a rich immune landscape with therapeutic implications (Bulk RNA-seq part) 47 samples shares microenvironment, therapeutic
- GSE148071 Comprehensive Profiling of Cancer Cells and Their Microenvironment in Advanced NSCLC 42 samples shares microenvironment, advanced
- GSE311200 Comprehensive analysis of the correlation between circulating biomarkers and tumor-immune microenvironment in advanced or recurrence non-small cell lung cancer in various treatment options, i.e., immunotherapy, EGFR TKI, and chemotherapy 41 samples shares microenvironment, advanced
- GSE198315 Multiregional single-cell profiling reveals extensive field cancerization and an immunosuppressive microenvironment in oral squamous cell carcinoma 36 samples shares immunosuppressive, microenvironment
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.