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The impact of U2AF2 deficiency on gene expression in ovarian cancer cells

GSE294020 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/21 Platform GPL21290
Summary
U2AF2 is an RNA processing-related factor that has a substantial impact on various cellular processes and is also closely associated with cancer development.Here, functional experiments demonstrated that U2AF2 significantly promotes ovarian cancer progression.RNA-seq analysis revealed that differentially expressed genes downstream of U2AF2 are significantly enriched in the Wnt signaling pathway, which was validated by Western blot.In summary, our data provide new molecular insights into ovarian cancer.
Published in
THOC1 binds to U2AF2 and regulates ovarian cancer progression through the beta-catenin / c-myc / cyclinD1 signaling pathway
Feng Y, Liu J, Zhang S et al. · Cancer cell international 2025 · PMID 41372894 · doi:10.1186/s12935-025-04034-z
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Also filed as BioProject PRJNA1247880 and SRA study SRP577155. Searching any of these in the dataset finder brings you back here.

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