SIRT6 Overexpression Counteracts Chromatin Aging [RNA-Seq]
RNA-seq (gene expression) · mouse · 28 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 28 samples: 8 × young_wt vs 8 × old_wt vs 6 × young_sirt6_tg vs 6 × old_sirt6_tgGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- SIRT6 overexpression counteracts chromatin aging in the male murine liverNature communications · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE294067_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1247990 and SRA study SRP577249. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 28 samples.
How we read this: 4 replicated groups read from 28 sample titles; they account for 28 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8898214 young_wt_1 young_wt
- GSM8898215 young_wt_2 young_wt
- GSM8898216 young_wt_3 young_wt
- GSM8898217 young_wt_4 young_wt
- GSM8898218 young_wt_5 young_wt
- GSM8898219 young_wt_6 young_wt
- GSM8898220 young_wt_7 young_wt
- GSM8898221 young_wt_8 young_wt
- GSM8898222 young_sirt6_tg_9 young_sirt6_tg
- GSM8898223 young_sirt6_tg_10 young_sirt6_tg
- GSM8898224 young_sirt6_tg_11 young_sirt6_tg
- GSM8898225 young_sirt6_tg_12 young_sirt6_tg
- GSM8898226 young_sirt6_tg_13 young_sirt6_tg
- GSM8898227 young_sirt6_tg_14 young_sirt6_tg
- GSM8898228 old_wt_15 old_wt
- GSM8898229 old_wt_16 old_wt
- GSM8898230 old_wt_17 old_wt
- GSM8898231 old_wt_18 old_wt
- GSM8898232 old_wt_19 old_wt
- GSM8898233 old_wt_20 old_wt
- GSM8898234 old_wt_21 old_wt
- GSM8898235 old_wt_22 old_wt
- GSM8898236 old_sirt6_tg_23 old_sirt6_tg
- GSM8898237 old_sirt6_tg_24 old_sirt6_tg
- GSM8898238 old_sirt6_tg_25 old_sirt6_tg
- GSM8898239 old_sirt6_tg_26 old_sirt6_tg
- GSM8898240 old_sirt6_tg_27 old_sirt6_tg
- GSM8898241 old_sirt6_tg_28 old_sirt6_tg
- GSE294085 SIRT6 Overexpression Counteracts Chromatin Aging [ChIP-Seq] 74 samples shares sirt6, overexpression, counteracts, chromatin, aging
- GSE294103 SIRT6 Overexpression Counteracts Chromatin Aging [ATAC-Seq_tg] 28 samples shares sirt6, overexpression, counteracts, chromatin, aging
- GSE166225 Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates [RNA-seq] 288 samples shares chromatin, rna-seq
- GSE299114 Endothelial Cells retain inflammatory memory through chromatin remodeling [RNA-Seq 2] 53 samples shares chromatin, rna-seq
- GSE294772 Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging [snATAC-Seq] [10X Multiome] 142 samples shares chromatin, aging
- GSE204933 Age-associated chromatin reorganization drives overexpression of a novel Btaf1 variant regulating HSC self-renewal and MkP differentiation in male mice 82 samples shares overexpression, chromatin
- GSE280663 Targeting the chromatin remodeler BAZ2B mitigates liver aging and fibrosis 46 samples shares chromatin, aging
- GSE279026 cGAS deficient mice display premature aging associated with loss of chromatin organization, derepression of LINE1 elements and induction of inflammation 33 samples shares chromatin, aging
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.