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Study on the Effects of Retinoids on UVR-Induced Skin Photoaging [RNA-seq]

GSE294121 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2026/01/20 Platform GPL16791
Summary
Photoaging contributes to up to 80% of visible facial aging signs, making it a major dermatological concern. While retinoids such as retinol and all-trans retinoic acid (ATRA) promote extracellular matrix (ECM) regeneration, their side effects limit widespread use. We propose that hydroxypinacolone 9-cis retinoate (9-cis HPR), a derivative of 9-cis retinoic acid, activates both retinoic acid receptor (RAR) and retinoid X receptor (RXR), enhancing efficacy while minimizing irritation. However, its in vivo anti-photoaging effects remain underexplored. This study evaluates 9-cis HPR in the UVR-damaged SKH-1 mouse model, investigating its role in inflammation control, ECM regeneration, and melanogenesis suppression.
Published in
Hydroxypinacolone 9-cis retinoate mitigates UV-induced photoaging by modulating extracellular matrix, fibroblasts, inflammation, and melanogenesis
Hu F, Yu J, Zheng C et al. · The Journal of investigative dermatology 2026 · PMID 41644086 · doi:10.1016/j.jid.2026.01.020
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Also filed as BioProject PRJNA1245253. Searching any of these in the dataset finder brings you back here.

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