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Bulk RNA seq of in vitro co- culture of distinct subtypes of oral cancer associated primary fibroblasts and oral cancer cell line

GSE294386 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/04/11 Platform GPL16791
Summary
Heterogeneity in oral cancer associated fibroblasts (CAFs)in tumor microenvironment modulate plasticity of malignant epithelial cells to drive tumorigenesis, ultimately leading to poorer clinical outcome. Myofibroblastically differentiated CAFs induce stochastic plasticity in oral cancer cells. We co-cultured non-myofibroblasts and myofibroblasts with oral cancer cell lines to understand distinct CAF driven cancer cell transcriptional reprogramming.
Published in
Tie2 activity in cancer associated myofibroblasts serves as novel target against reprogramming of cancer cells to embryonic-like cell state and associated poor prognosis in oral carcinoma patients
Mitra P, Saha U, Stephen KJ et al. · Journal of experimental & clinical cancer research : CR 2025 · PMID 40349056 · doi:10.1186/s13046-025-03405-8
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Also filed as BioProject PRJNA1249372 and SRA study SRP577929. Searching any of these in the dataset finder brings you back here.

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