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Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus [ChIP-seq_mm]

GSE294476 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/08/04 Platform GPL24247
Summary
Extreme metabolic adaptations can elucidate genetic programs governing mammalian metabolism. Here we used convergent evolutionary changes in hibernating lineages to define conserved cis-regulatory elements (CREs) and metabolic programs. We characterized mouse hypothalamus gene expression and chromatin dynamics across fed, fasted, and refed states, then used comparative genomics of hibernating versus non-hibernating lineages to identify cis-elements with convergent changes in hibernators. Multi-omics approaches pinpointed CREs, hub genes, regulatory programs, and cell types underlying lineage divergence. Hibernators accumulated loss-of-function effects for CREs regulating hypothalamic responses, and the refeeding period after fasting served as a key phase for molecular processes with convergent evolutionary changes. This work provides a genetic framework for harnessing hibernator adaptations to understand human metabolic control.
Published in
Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus
Ferris E, Gonzalez Murcia JD, Rodriguez AC et al. · Science (New York, N.Y.) 2025 · PMID 40743333 · doi:10.1126/science.adp4025
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Also filed as BioProject PRJNA1238491 and SRA study SRP571763. Searching any of these in the dataset finder brings you back here.

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