Obesity promotes urinary tract infection by disrupting urothelial immune defenses
RNA-seq (gene expression) · mouse · 28 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 28 samples: 4 × female LFD urothelium vs 4 × female HFD urothelium vs 4 × male HFD urothelium vs 4 × male LFD urotheliumGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signalingiScience · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE294660_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1251054 and SRA study SRP578771. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 28 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6645263 female LFD urothelium 1 female LFD urothelium
- GSM6645264 female LFD urothelium 2 female LFD urothelium
- GSM6645265 female LFD urothelium 3 female LFD urothelium
- GSM6645266 female LFD urothelium 4 female LFD urothelium
- GSM6645267 female HFD urothelium 1 female HFD urothelium
- GSM6645268 female HFD urothelium 2 female HFD urothelium
- GSM6645269 female HFD urothelium 3 female HFD urothelium
- GSM6645270 female HFD urothelium 4 female HFD urothelium
- GSM6645271 male HFD urothelium 1 male HFD urothelium
- GSM6645272 male HFD urothelium 2 male HFD urothelium
- GSM6645273 male HFD urothelium 3 male HFD urothelium
- GSM6645274 male HFD urothelium 4 male HFD urothelium
- GSM6645275 male LFD urothelium 1 male LFD urothelium
- GSM6645276 male LFD urothelium 2 male LFD urothelium
- GSM6645277 male LFD urothelium 3 male LFD urothelium
- GSM6645278 male LFD urothelium 4 male LFD urothelium
- GSM6953258 11613 LOW FAT DIET FEMALE baseline urothelium
- GSM6953259 11614 LOW FAT DIET FEMALE baseline urothelium
- GSM6953260 11616 LOW FAT DIET FEMALE baseline urothelium
- GSM6953261 11606 HIGH FAT DIET FEMALE baseline urothelium
- GSM6953264 11524 HIGH FAT DIET MALE baseline urothelium
- GSM6953266 11528 LOW FAT DIET MALE baseline urothelium
- GSM6953267 11529 LOW FAT DIET MALE baseline urothelium
- GSM6953268 HFD1 HIGH FAT DIET FEMALE baseline urothelium
- GSM6953269 HFD2 HIGH FAT DIET FEMALE baseline urothelium
- GSM6953272 11441 HIGH FAT DIET MALE baseline urothelium
- GSM6953273 11444 HIGH FAT DIET MALE baseline urothelium
- GSM6953279 11391 LOW FAT DIET MALE baseline urothelium
- GSE274057 Whole transcriptome sequencing for upper tract urothelial carcinoma (UTUC) of BALB/c female mice treated with N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) 37 samples shares urothelial, tract
- GSE254704 Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice 32 samples shares promotes, obesity
- GSE242882 CPEB2-activated Prdm16 translation promotes brown adipocyte function and prevents obesity 22 samples shares promotes, obesity
- GSE271333 Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism 16 samples shares disrupting, promotes
- GSE256409 Antibody Fc-receptor common gamma chain FcεR1γ stabilizes cell surface receptors in group 3 innate lymphoid cells and promotes anti-infection immunity 20 samples shares promotes
- GSE276049 Loss of pulmonary tissue protection promotes severe Aspergillus fumigatus infection during Influenza A Virus 12 samples shares promotes
- GSE228457 IL-7 mediated immunoregulatory feedback loop promotes dampening of immune effector functions by hypoinflammatory monocytes. 305 samples shares promotes
- GSE218178 Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance 183 samples shares promotes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.