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Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 to establish T cell niches

GSE294695 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/04/22 Platform GPL24247
Summary
Secondary lymphoid organs are organized by fibroblastic reticular cells (FRCs), which direct immune cell positioning and support adaptive immunity. However, the mechanisms driving FRC subset differentiation remain unclear. To uncover signaling pathways involved in this process, we performed ATAC-seq on lymph node FRCs lacking Notch2. Our data reveal chromatin remodeling changes in the absence of Notch signaling.
Published in
Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches
Alouche N, Cannelle H, Favre S et al. · Immunity 2026 · PMID 42030954 · doi:10.1016/j.immuni.2026.03.023
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Also filed as BioProject PRJNA1251098 and SRA study SRP578840. Searching any of these in the dataset finder brings you back here.

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