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Engineered cytokine-secreting cells to prevent foreign body response against implants

GSE294864 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2026/04/06 Platform GPL24247
Summary
Foreign body response hinders the long-term functionality of implants such as microencapsulated cell therapies. To address this issue, we delivered encapsulated engineered cells that secrete targeted cytokines to mitigate fibrosis on microcapsules. Here, we quantify immune profile change due to these encapsulated cytokine-secreting cells in mice. We identified that IL10 prevents inflammatory response while IL12 impairs the TGF-beta pathway to mitigate fibrosis.
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Direct links to NCBI, no account and no request form: the whole study as GSE294864_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1251884 and SRA study SRP579343. Searching any of these in the dataset finder brings you back here.

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