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Prdm1-creER fate maps cells with memory and effector potential [RNAseq_Prdm1tdt]

GSE294880 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/10/02 Platform GPL34290
Summary
The transcription factor Blimp1 (encoded by Prdm1) is upregulated in CD8+ T cells early in responses to viral infection. The role of Blimp1 in promoting effector differentiation suggests that it may enforce commitment of cells to an effector fate. However, the target genes that Blimp1 regulates to promote effector differentiation remain incompletely defined. To examine genes associated with Prdm1 induction early in an immune response, we sorted Prdm1-creERT2 fate mapped and non-fate mapped cells on 6 days post LCMV-Arm infection after fate mapping on 3 and 4 days post infection.
Published in
The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8(+) T cells
Murphy MK, McCullen M, Deffenbaugh JL et al. · Immunity 2025 · PMID 41043414 · doi:10.1016/j.immuni.2025.09.008
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Also filed as BioProject PRJNA1251664 and SRA study SRP579109. Searching any of these in the dataset finder brings you back here.

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