← BioTransfer GEO Dataset Finder
GEO series

A spatiotemporal atlas of orchiectomy-induced modulation of cellular composition and gene expression in the mouse prostate [scRNA-seq]

GSE295192 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/12/02 Platform GPL24247
Summary
Mice models are commonly used to further our understanding of the function of the prostate and response to androgen depletion. We used both spatial transcriptomics and single cell transcriptomics to determine how the mouse prostate degrades after castration. We identified changes in each of the prostate lobes that couuld be tracked over time as well as changes in the immune profile and of the composition of fibroblasts within the prostate. In addition to several previously identified fibroblast subtypes that we were able to show were altered in response to androgen depletion, we identified a novel fibroblast subtype present only in the castrated prostate.
Published in
A spatiotemporal atlas of orchiectomy-induced androgen deprivation-mediated modulation of cellular composition and gene expression in the mouse prostate
Shelley G, May A, Robinson T et al. · Neoplasia (New York, N.Y.) 2025 · PMID 40974890 · doi:10.1016/j.neo.2025.101230
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE295192_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1253686 and SRA study SRP580227. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.