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Effects of TCF-1 de-repression on heterogeneity of chromatin states in memory and effector cells following acute infecton [scATAC-seq]

GSE295247 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/05/31 Platform GPL24247
Summary
The transcription factor TCF-1 is downregulated during effector differentiation of CD8+ T cells. However, how its downregulation impacts epigenetic regulation of different effector- and memory-biased populations remains unclear. Here, we generate mice in which TCF-1 fails to become downregulated in differentiated effector cells and probe the epigenetic impact of TCF-1 retention on gene accessibiltiy patterns and moif enrichment patterns in CD8+ T cells on 8 dpi with LCMV-13 using scATAC-seq.
Published in
The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8(+) T cells
Murphy MK, McCullen M, Deffenbaugh JL et al. · Immunity 2025 · PMID 41043414 · doi:10.1016/j.immuni.2025.09.008
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Also filed as BioProject PRJNA1253759 and SRA study SRP580282. Searching any of these in the dataset finder brings you back here.

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