GEO series
Cellular and molecular dysregulation of the esophageal epithelium in systemic sclerosis
GSE295274
Homo sapiens
Expression profiling by high throughput sequencing
37 samples
2025/10/10
GPL24676
Summary
Individuals with systemic sclerosis (SSc) often suffer from chronic acid reflux and dysphagia due to loss of esophageal motility. However, the pathogenesis of esophageal dysmotility in SSc is poorly understood. To determine whether distinct changes in esophageal epithelial cells contribute to impaired motility in SSc, we investigated the stratified squamous esophageal epithelium from proximal and distal biopsies using single-cell RNA sequencing (n=306,372 cells) in individuals with SSc compared those with gastroesophageal reflux disease (GERD) as well as healthy controls.
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