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Transcriptomic profiling of primary human dermal fibroblasts treated with BoNTA

GSE295291 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/27 Platform GPL24676
Summary
This study aimed to explore the transcriptomic changes in primary human dermal fibroblasts upon treatment with Botulinum toxin type A (BoNTA). BoNTA is a neurotoxin known for its clinical use in dermatology, and emerging evidence suggests potential antifibrotic and anti-inflammatory effects at the cellular level. We performed high-throughput RNA sequencing to assess the global gene expression profiles in fibroblasts treated with BoNTA (1 U/ml) for 24 hours, compared with vehicle control (PBS). This dataset provides valuable insights into the molecular mechanisms of BoNTA in skin-resident fibroblasts and offers a reference for future investigations into its therapeutic roles in fibrotic skin diseases.
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Direct links to NCBI, no account and no request form: the whole study as GSE295291_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1254132 and SRA study SRP580471. Searching any of these in the dataset finder brings you back here.

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