GEO series

Comprehensive analysis of miRNA expression profiles in IDA, IPMA, IPMC and cancer cell line

GSE29542 Homo sapiens (human) Non-coding RNA profiling 22 samples Submitted 2011/05/30 Platform GPL8227

At a glance

Non-coding RNA profiling · human · 22 samples

What it is: Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
Organism: Homo sapiens (human)
Topic: Pancreatic cancerThis series is part of our curated briefing on it.
Samples: 22 samples
Data you can get: A processed expression table (series matrix) and the array files, from NCBI.

Summary (written by the submitters)

This study identified differentially expressed miRNAs exclusively in invasive ductal adenocarcinoma. The epithelial-mesenchymal transition (EMT) is a critical step for pancreatic cancer cells as an entry of metastatic disease. Wide variety of cytokines and signaling pathways are involved in this complex process while the entire picture is still cryptic.

Read the full summary ↓

Recently, miRNA was found to regulate cellular function including EMT by targeting multiple mRNAs. We performed comprehensive analysis of miRNA expression profiles in invasive ductal adenocarcinoma (IDA), intraductal papillary mucinous adenoma (IPMA), intraductal papillary mucinous carcinoma (IPMC) and human pancreatic cancer cell line to elucidate essential miRNAs which regulate invasive growth of pancreatic cancer cells. Along with higher expression of miR-21 which has been shown to be highly expressed in IDA, reduced expression of miR-126 in IDA and pancreatic cancer cell line was detected. Re-expression of miR-126 in pancreatic cancer cells resulted in reduced cellular migration, invasion and induction of epithelial marker E-cadherin. We demonstrated for the first time that the miR-126 plays essential role in the inhibition of invasive growth of pancreatic cancer cells.

This dataset

Open GSE29542 in finder → Find more human datasets → Pancreatic cancer landscape →

Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗

3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE29542_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

Also filed as BioProject PRJNA141445. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 22064652) ↗

Samples in this study

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+ 22 more — browse all 22 samples with per-sample file links →

More Pancreatic cancer datasets

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GSE147549 Transcriptomic profiling of human pancreatic cancer-derived cell lines MiaPACA-2 depleted of TRIP12 mRNA compared to control cells 8 samples same disease briefing · shares line
GSE288221 RNA sequencing human melanoma, glioblastoma and pancreatic adenocarcinoma cell lines 32 samples same disease briefing · shares line
GSE268524 A robust circulating microRNA signature for diagnosis and early detection in pancreatobiliary cancer 1403 samples same disease briefing
GSE224502 RNA-Seq profiles of pancreatic adenocarcinoma PANC-1 and osteosarcoma U2OS cells with Pin1 knocking down 18 samples same disease briefing · shares profiles
GSE114778 Plasma miRNA expression profiling of pancreatic ductal adenocarcinoma patient, chronic pancreatitis patients and healthy population in China 15 samples same disease briefing · shares mirna
GSE125179 microRNA modulated networks of adaptive and innate immune response in pancreatic ductal adenocarcinoma 28 samples same disease briefing

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