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Multi-omics Reveals CCL3 Driving Neuronal Sensitization in Chronic Pruritus of Unknown Origin

GSE295457 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/11/21 Platform GPL18573
Summary
Chronic pruritus is a pathological condition associated with numerous systemic, dermatologic, and neurologic disorders. Chronic pruritus of unknown origin (CPUO) represents a distinct clinical subtype characterized by persistent itch without an identifiable underlying cause. While emerging evidence implicates neuroimmune dysregulation in chronic pruritus, the specific mechanisms driving CPUO remain poorly understood. Objective: To characterize the neuroimmune mechanisms underlying CPUO, with a focus on identifying potential diagnostic markers. Single-cell RNA sequencing of peripheral blood cells from patients and healthy controls was conducted. Single-cell transcriptomic analysis revealed dysregulated monocytes and hyperactive natural killer (NK) cells overexpressing CCL3.
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Also filed as BioProject PRJNA1254712 and SRA study SRP580810. Searching any of these in the dataset finder brings you back here.

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