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A Hypothalamic Circuit that Modulates Feeding and Parenting Behaviors

GSE295610 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/05/05 Platform GPL24247
Summary
Female lactating mammals undergo many physiological and behavioral changes postpartum to care for newborn offspring and meet the increased caloric demands of milk production. To uncover the neural correlates of these postpartum adaptations, we investigated how gene expression in two hypothalamic regions -- the arcuate nucleus (ARC) and the medial preoptic area (MPOA) -- is regulated by food deprivation and lactation. To this end, we employed 10x Genomics scRNA-seq in the ARC and MPOA of 4 groups of age-matched female mice: sated virgins (VS), fasted virgins (VF), sated mothers (MS), and fasted mothers (MF).
Published in
A hypothalamic circuit that modulates feeding and parenting behaviours
Alcantara IC, Li C, Gao C et al. · Nature 2025 · PMID 40739345 · doi:10.1038/s41586-025-09268-5
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Also filed as BioProject PRJNA1255473 and SRA study SRP581238. Searching any of these in the dataset finder brings you back here.

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