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First Generation Tools for the Modeling of Capicua-Family Fusion Oncoprotein-Driven Cancers (April 2023 Dataset)

GSE295624 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/05/13 Platform GPL24676
Summary
The rearrangement of separate genes into neomorphic fusion oncogenes can occur after chromosomal damage and repair, causing cancer. In the case of sarcomas, several tumor types are driven by fusion oncogenes comprised of various partner genes. We study fusions involving capicua (CIC), a developmental transcriptional repressor whose fusion to 3' partner genes including DUX4, NUTM1, and LEUTX drives devastating tumors of the soft tissue, central nervous system, and spine. Here we develop the first tools to investigate previously understudied fusions of CIC and ATXN1 and express them in 293T cells to uncover convergent/divergent biology between various CIC-family fusions depending on what the specific partner genes are.
Published in
First Generation Tools for the Modeling of Capicua (CIC) - Family Fusion Oncoprotein-Driven Cancers
Luck C, Jacobs KA, Riad J et al. · bioRxiv : the preprint server for biology 2025 · PMID 40463157 · doi:10.1101/2025.05.13.653825
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Also filed as BioProject PRJNA1255495 and SRA study SRP581277. Searching any of these in the dataset finder brings you back here.

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