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Effect of overexpression different alleles C/G at locus rs149707223 of LINC02449 on gene expression of SK-N-SH cells(Human neuroblastoma cell line)

GSE295729 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/16 Platform GPL11154
Summary
Long non-coding RNA (LncRNA) is a significant epigenetic regulatory factor, and its allele-specific expression (ASE) may play an important role in mental disorders. Therefore, clarifying the relationship between allele-specific expression (ASE) of lncRNA and mental disorders is of great significance for an in-depth understanding of the molecular mechanism of mental disorders. We here report that ASE-driven allelic shift in LINC02449 in Bipolar disorder (BD) and schizophrenia (SZ) contributes to behavioral and synaptic abnormalities in mice. We found that when the alternative allele of LINC02449 was overexpressed in cells and mouse brain regions, the expression of differentially expressed genes would be significantly enriched in mental disorders, mediating enhanced synaptic excitability transmission. Taken together, our data supported that LINC02449 overexpression, driven by the rs149707223 alternative allele, affects the disease susceptibility of BD/SZ.
Published in
Gain of Alternative Allele Expression of LINC02449 at rs149707223 in Schizophrenia and Bipolar Disorder: Inducing Synaptic Transmission and Behavioral Deficits in Mice
Yang T, Liu JM, Chen Q et al. · Nature communications 2025 · PMID 41188235 · doi:10.1038/s41467-025-64717-z
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Also filed as BioProject PRJNA1256269 and SRA study SRP581746. Searching any of these in the dataset finder brings you back here.

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