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UPF1 knockdown in IPSC-derived cortical neurons

GSE296063 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/05/01 Platform GPL16791
Summary
UPF1 is a key regulator of the nonsense-mediated decay (NMD) RNA degradation/quality control pathway. In this study, UPF1 knockdown was performed in IPSC-derived cortical-like neurons (NGN2) to characterise the transcriptome changes upon loss of UPF1 and NMD activity
Published in
Altered mRNA transport and local translation in i3Neurons with RNA-binding protein knockdown
Dargan R, Mikheenko A, Johnson NL et al. · Nucleic acids research 2025 · PMID 40737092 · doi:10.1093/nar/gkaf709
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Also filed as BioProject PRJNA1256902 and SRA study SRP582221. Searching any of these in the dataset finder brings you back here.

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