Combinatorial Immunotherapeutic Strategies in Liver Cancer
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- PolyIC as an adjuvant outperforms anti-VEGF in combination with anti-PD-L1 therapy in mouse liver tumor modelsHepatology communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296090_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1257769 and SRA study SRP582563. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8964981 C1-8-liver,RAS/MYC HTVi induce tumor model without treatment
- GSM8964982 C5-8-liver,RAS/MYC HTVi induce tumor model without treatment
- GSM8964983 C18-8-liver,RAS/MYC HTVi induce tumor model without treatment
- GSM8964984 C5-3-liver,RAS/MYC HTVi induce tumor model without treatment
- GSM8964985 C18-3-liver,RAS/MYC HTVi induce tumor model without treatment
- GSM8964986 CV6-3-liver,RAS/MYC HTVi induce tumor model without treatment
- GSM8964987 C1-45-liver,RAS/MYC HTVi induce tumor model without treatment
- GSM8964988 C5-45-liver,RAS/MYC HTVi induce tumor model without treatment
- GSM8964989 C18-45-liver,RAS/MYC HTVi induce tumor model without treatment
- GSM8964990 P11-8-liver,oncogene induced primary HCC tumor model, treated with antibody
- GSM8964991 P2-8-liver,oncogene induced primary HCC tumor model, treated with antibody
- GSM8964992 PL19-8-liver,oncogene induced primary HCC tumor model, treated with antibody
- GSM8964993 P111-3-liver,oncogene induced primary HCC tumor model, treated with antibody
- GSM8964994 P2-3-liver,oncogene induced primary HCC tumor model, treated with antibody
- GSM8964995 PL19-3-liver,oncogene induced primary HCC tumor model, treated with antibody
- GSM8964996 P2-45-liver,oncogene induced primary HCC tumor model, treated with antibody
- GSM8964997 P11-45-liver,oncogene induced primary HCC tumor model, treated with antibody
- GSM8964998 PL19-45-liver,oncogene induced primary HCC tumor model, treated with antibody
- GSE325237 Higher basal tumor immune activity coupled with a systemic immune response improves liver cancer outcomes 116 samples shares liver
- GSE236129 Activation of RAS/MEK/ERK signaling drives biliary differentiation in primary liver cancer [112UE] 80 samples shares liver
- GSE228579 Chronic stress disrupts hepatic homeostasis and accelerates liver cancer progression through ADRB2 signaling 66 samples shares liver
- GSE313654 Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer [RNAseq_MycRux] 58 samples shares liver
- GSE324743 Hepatocytes promote liver metastasis of pancreatic cancer by providing exogenous serine 24 samples shares liver
- GSE279096 Bile acid synthesis impedes tumor-specific T cell responses during liver cancer [RNA-seq1] 24 samples shares liver
- GSE232264 Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [Liver] 18 samples shares liver
- GSE266900 Cxcr3 promotes protection from colorectal cancer liver metastasis by driving NK infiltration and plasticity 18 samples shares liver
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.