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Hypothermic machine perfusion alleviates DCD graft liver injury by inducing the expression of KLF2 and promoting macrophage efferocytosis

GSE296118 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/05 Platform GPL24676
Summary
This study aims to investigate the protective effects and underlying mechanisms of hypothermic machine perfusion (HMP) on ischemia-reperfusion injury (IRI) in liver grafts from donation after cardiac death (DCD), with a specific focus on the regulation of KLF2 expression and its role in modulating macrophage efferocytosis.
Published in
Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling
Deng Q, Liu Z, Ye Q et al. · International journal of molecular medicine 2026 · PMID 41645764 · doi:10.3892/ijmm.2026.5756
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Also filed as BioProject PRJNA1257820 and SRA study SRP582608. Searching any of these in the dataset finder brings you back here.

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