GEO series
Androgenic Effects of 11-Oxygenated Androgens in Castration-Resistant Prostate Cancer
GSE296144
Homo sapiens
Expression profiling by high throughput sequencing
63 samples
2025/10/10
GPL24676
Summary
Investigations of CRPC cell models demonstrate that both 11oxygenated androgens 11Ketotestesterone (11KT) and 11-hydroxytestosterone (11OHT) drive robust AR-mediated proliferative responses and significantly modulate gene and protein expression profiles, paralleling canonical androgens. They also exhibit unique transcriptional and post-transcriptional effects that include potential AR-independent pathways. Furthermore, the AR antagonist enzalutamide effectively inhibits their androgenic actions, suggesting they are primarily AR-mediated.
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Paper (PMID 41257618) ↗
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