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Autophagy related 14 regulates liver homeostasis and function

GSE296179 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/07 Platform GPL24247
Summary
Autophagy regulated 14 (ATG14) is a key regulator of autophagy; however, its role in the liver remains poorly understood. This study aimed to investigate the hepatocyte-specific function of ATG14 in vivo. We generated Atg14 hepatocyte-specific knockout (HepKO) mice using adeno-associated virus (AAV) to deliver thyroxine-binding globulin (TBG) gene promoter-driven Cre into Atg14 floxed mice at an adult age and fed control and knockout mice with a Western diet for 4 weeks.
Published in
Autophagy related 14 protects against liver injury by inhibiting multiple cell death pathways
Kim HG, Huang M, Wang S et al. · eGastroenterology 2025 · PMID 41132151 · doi:10.1136/egastro-2025-100181
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Also filed as BioProject PRJNA1258151 and SRA study SRP582764. Searching any of these in the dataset finder brings you back here.

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