Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for induction of an adaptive stress response
RNA-seq (gene expression) · human · 30 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Acute myeloid leukemiaThis series is part of our curated briefing on it.
- Samples
- 30 samples: 30 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress responseLeukemia · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296181_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1258162 and SRA study SRP582768. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 30 sample titles: 30 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8966540 Sample 1245 leukemic blasts
- GSM8966541 Sample 1532 leukemic blasts
- GSM8966542 Sample 1737 leukemic blasts
- GSM8966543 Sample 1756 leukemic blasts
- GSM8966544 Sample 2077 leukemic blasts
- GSM8966545 Sample 2293 leukemic blasts
- GSM8966546 Sample 2320 leukemic blasts
- GSM8966547 Sample 2582 leukemic blasts
- GSM8966548 Sample 2753 leukemic blasts
- GSM8966549 Sample 2817 leukemic blasts
- GSM8966550 Sample 2837 leukemic blasts
- GSM8966551 Sample 2910 leukemic blasts
- GSM8966552 Sample 3043 leukemic blasts
- GSM8966553 Sample 3344 leukemic blasts
- GSM8966554 Sample 346 leukemic blasts
- GSM8966555 Sample 354 leukemic blasts
- GSM8966556 Sample 3875 leukemic blasts
- GSM8966557 Sample 3965 leukemic blasts
- GSM8966558 Sample 4217 leukemic blasts
- GSM8966559 Sample 432 leukemic blasts
- GSM8966560 Sample 4454 leukemic blasts
- GSM8966561 Sample 474 leukemic blasts
- GSM8966562 Sample 4748 leukemic blasts
- GSM8966563 Sample 5052 leukemic blasts
- GSM8966564 Sample 5091 leukemic blasts
- GSM8966565 Sample 5402 leukemic blasts
- GSM8966566 Sample 5653 leukemic blasts
- GSM8966567 Sample 6063 leukemic blasts
- GSM8966568 Sample 6378 leukemic blasts
- GSM8966569 Sample 935 leukemic blasts
- GSE137574 Kevetrin induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells 24 samples same disease briefing · shares tp53
- GSE122515 Bonn Dataset 3 of meta-analysis on AML classification, RNAseq dataset 0 samples same disease briefing · shares aml
- GSE137851 The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia 387 samples same disease briefing
- GSE270185 Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia 249 samples same disease briefing
- GSE303795 Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia 6 samples same disease briefing
- GSE129437 Genome-wde mapping of BRD9 binding sites and gene expression changes upon BRD9 knockdown 6 samples same disease briefing
- GSE309028 TP53 deficiency in AML induces resistance to T-cell engagers through an immunosuppressive secretome 12 samples shares tp53, aml
- GSE232130 Leucegene: AML sequencing (GRCh38 reference) 691 samples shares aml
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.