Heterogeneity and Homogeneity in Treg responses to Interleukin-2 [RNAseq1: IL2/JES6-1 timecourse]
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 8 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Dynamics and variegation in the Treg response to Interleukin-2Proceedings of the National Academy of Sciences of the United States of America · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296240_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1258263 and SRA study SRP582846. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 8 replicated groups read from 18 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8967568 Treg_Sp_IL2_JES6_128h_1 Treg_Sp_IL2_JES6_128h
- GSM8967569 Treg_Sp_IL2_JES6_128h_2 Treg_Sp_IL2_JES6_128h
- GSM8967570 Treg_Sp_IL2_JES6_64h_1 Treg_Sp_IL2_JES6_64h
- GSM8967571 Treg_Sp_IL2_JES6_64h_2 Treg_Sp_IL2_JES6_64h
- GSM8967572 Treg_Sp_IL2_JES6_24h_1 Treg_Sp_IL2_JES6_24h
- GSM8967573 Treg_Sp_IL2_JES6_24h_2 Treg_Sp_IL2_JES6_24h
- GSM8967574 Treg_Sp_IL2_JES6_16h_1 Treg_Sp_IL2_JES6_16h
- GSM8967575 Treg_Sp_IL2_JES6_16h_2 Treg_Sp_IL2_JES6_16h
- GSM8967576 Treg_Sp_IL2_JES6_8h_1 Treg_Sp_IL2_JES6_8h
- GSM8967577 Treg_Sp_IL2_JES6_8h_2 Treg_Sp_IL2_JES6_8h
- GSM8967578 Treg_Sp_IL2_JES6_4h_1 Treg_Sp_IL2_JES6_4h
- GSM8967579 Treg_Sp_IL2_JES6_4h_2 Treg_Sp_IL2_JES6_4h
- GSM8967580 Treg_Sp_IL2_JES6_2h_1
- GSM8967581 Treg_Sp_IL2_JES6_1h_1 Treg_Sp_IL2_JES6_1h
- GSM8967582 Treg_Sp_IL2_JES6_1h_2 Treg_Sp_IL2_JES6_1h
- GSM8967583 Treg_Sp_PBS_128h_1
- GSM8967584 Treg_Sp_PBS_2h_1 Treg_Sp_PBS_2h
- GSM8967585 Treg_Sp_PBS_2h_2 Treg_Sp_PBS_2h
- GSE302070 Heterogeneity and Homogeneity in Treg responses to Interleukin-2 [RNAseq2: Differential activation of Immune cell types by IL2-Immunocytokines] 45 samples shares il2, heterogeneity, interleukin-2, homogeneity, treg
- GSE297025 Heterogeneity and Homogeneity in Treg responses to Interleukin-2 67 samples shares heterogeneity, interleukin-2, homogeneity, treg
- GSE43969 Reconstruction of the dynamic regulatory network that controls Th17 cell differentiation by systematic perturbation in primary cells (Affymetrix timecourse IL23 KO) 20 samples shares il2, timecourse
- GSE279606 Distinct Vps34-orchestrated signaling processes dictate the transitional heterogeneity and functional adaptation of effector Treg cells. 55 samples shares heterogeneity, treg
- GSE283255 Distinct Vps34-orchestrated signaling processes dictate the transitional heterogeneity and functional adaptation of effector Treg cells [ATAC-seq2] 14 samples shares heterogeneity, treg
- GSE283256 Distinct Vps34-orchestrated signaling processes dictate the transitional heterogeneity and functional adaptation of effector Treg cells [ATAC-seq1] 10 samples shares heterogeneity, treg
- GSE75109 Single-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [IL1B_IL6_IL23-48h-IL-17A/GFP+] 139 samples shares il2
- GSE215179 Selective requirement of 3D genomic organization for the Mdm1-Il22-Ifng locus regulation in initial Th1 cell lineage specification and differentiation 30 samples shares il2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.