Loss of the USP22 deubiquitylase confers resistance to chemotherapy in small cell lung cancer [CUT&Tag]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 23 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Small cell lung cancerThis series is part of our curated briefing on it.
- Samples
- 23 samples: 21 distinct titles, 1 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296258_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1258284. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 23 sample titles: 21 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8967722 FHSC14_IgG1
- GSM8967723 FHSC14_IgG2
- GSM8967724 FHSC14_IgG3
- GSM8967725 FHSC14_sgCtrl_SAL1_H3K27me3
- GSM8967726 FHSC14_sgCtrl_SAL2_H3K27me3
- GSM8967727 FHSC14_sgCtrl_SAL3_H3K27me3
- GSM8967728 FHSC14_sgUSP22_SAL1_H3K27me3
- GSM8967729 FHSC14_sgUSP22_SAL2_H3K27me3
- GSM8967730 FHSC14_sgUSP22_SAL3_H3K27me3
- GSM8967731 FHSC14_sgCtrl_CE1_H3K27me3
- GSM8967732 FHSC14_sgCtrl_CE2_H3K27me3
- GSM8967733 FHSC14_sgCtrl_CE3_H3K27me3
- GSM8967734 FHSC14_sgUSP22_CE1_H3K27me3
- GSM8967735 FHSC14_sgUSP22_CE2_H3K27me3
- GSM8967736 FHSC14_sgUSP22_CE3_H3K27me3
- GSM8967737 FHSC14_sgCtrl_SAL1_H2AK119ub
- GSM8967738 FHSC14_sgCtrl_SAL2_H2AK119ub
- GSM8967739 FHSC14_sgUSP22_SAL1_H2AK119ub
- GSM8967740 FHSC14_sgUSP22_SAL2_H2AK119ub
- GSM8967741 FHSC14_sgCtrl_CE1_H2AK119ub
- GSM8967742 FHSC14_sgCtrl_CE2_H2AK119ub
- GSM8967743 FHSC14_sgUSP22_CE1_H2AK119ub
- GSM8967744 FHSC14_sgUSP22_CE2_H2AK119ub
- GSE296261 Loss of the USP22 deubiquitylase confers resistance to chemotherapy in small cell lung cancer 43 samples same disease briefing · shares usp22, deubiquitylase, chemotherapy, resistance, confers, small, loss
- GSE296155 Loss of the USP22 deubiquitylase confers resistance to chemotherapy in small cell lung cancer [RNA-seq] 20 samples same disease briefing · shares usp22, deubiquitylase, chemotherapy, resistance, confers, small, loss
- GSE255095 An in vivo screening platform using PDX models reveals KEAP1, USP22 and other drivers of chemoresistance in small cell lung cancer 67 samples same disease briefing · shares usp22, resistance, small
- GSE297358 Loss of NOTCH2 Creates a TRIM28-Dependent Vulnerability in Small Cell Lung Cancer [ChIP-seq] 29 samples same disease briefing · shares small, loss
- GSE280219 ONECUT2 reprograms neuroendocrine fate and is an actionable therapeutic target in small cell lung cancer. 24 samples same disease briefing · shares cut, small
- GSE138474 Single-cell analyses reveal increasing intratumoral heterogeneity as an essential component of treatment resistance in small cell lung cancer 43 samples same disease briefing · shares resistance, small
- GSE297360 Loss of NOTCH2 Creates a TRIM28-Dependent Vulnerability in Small Cell Lung Cancer [human_bulk_RNA_seq] 14 samples same disease briefing · shares small, loss
- GSE280212 Mechanisms of drugs-resistance in small cell lung cancer III 12 samples same disease briefing · shares resistance, small
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.